The forecasted increase in the number of older people for this century will be accompanied by an increase of those with disabilities. Disability is usually preceded by a timely and highly topical condition named frailty, a disorder that encompasses changes associated with ageing, life styles and chronic diseases. Detect frailty and intervene on it is of outstanding importance to prevent disability, as recovery from disability is unlikely. FRAILOMICS aims to discover early biomarkers to be used in risk prediction and diagnosis of frailty by using combinations of clinical and laboratory setups.
Formation and fate of tyrosine nitrated proteins
Protein tyrosine nitration is an oxidative postranslational modification generated by peroxynitrite and other nitric oxide-derived oxidants. Nitrated proteins are associated with a variety of disease states and the aging process. In the current project we plan to make progress on the understanding of the biochemical mechanisms and biological consequences of protein tyrosine nitration. The experimental strategy encompasses biochemical and cell biology studies and integrates the expertise of the partner laboratories in Montevideo (Dr. Radi) and Dr. Grune on the biochemistry of protein tyrosine nitration and turnover of oxidized proteins, respectively.
Role of Protein Oxidation and Protein Aggregates in Aging and Neurodegeneration
Support: Various foundations and companies
Protein oxidation and aggregation seems to be a common feature of several neurodegenerative diseases and to some extent of physiological aging. It is not always clear why protein aggregation takes place, but a disturbance in the homeostasis between protein synthesis and protein degradation seems to be important. The result of this disturbance is the accumulation of modified proteins, which have various effects on the metabolism of affected cells.